Telephone sharing button Contact Us mailbox sharing button wuxixdc_info@wuxibiologics.com
arrow_left sharing button
arrow_right sharing button

Scientific Poster Download

Poster modified on 17/10/2023

Accelerated Prep-HPLC Purification and Lyophilization Process for the manufacturing of Linker-Payloads
Qu Haijun, Xu Feng, Lin Yuan, Shen Jianhua, Qiu Wenjun, Gu Wei, Li Jianqiang, Sudhir Patil
WuXi XDC (Shanghai), Co. Ltd.

Most linker-payloads used for ADCs need to be purified by prep-HPLC followed by lyophilization. Prep-HPLC generates large quantities of product fractions that require a time-consuming lyophilization process. In this poster, we discuss an enrichment process for reducing the volume of the Prep-HPLC pure product fractions to <1/4 of the original volume. As a result, the lyophilization time can be shortened significantly and the decomposition of the linker-payloads can be effectively prevented.

 

This scientific poster was originally presented during the 2023 World ADC Conference in San Diego

Discuss This Poster

To discuss the data in this poster, please complete the form on the following page to connect with our experts.

Connect with our Experts

Notice:

You are leaving WuXi Biologics Website, after which our Privacy Notice will not apply. Please keep it in mind the protection of your privacy. Are you willing to proceed?