Services & Solutions

Ready-Made Payloads & Linkers

Order now our high-quality GMP and non-GMP grade “Ready-to-Conjugate” Chemical Payloads, Linkers and Payload-Linkers

WuXi XDC offers a growing payload linker library of common payloads and linkers for a variety of R&D and pharmaceutical applications, including use as chemical intermediates in the production of antibody drug conjugates (ADCs) and other bioconjugates. Popular ADC payloads such as ADC MMAE, ADC MMAF, and Exatecan are available from inventory. These ready-to-use small molecule entities are available in both GMP and non-GMP grades.

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Payloads and Linkers

Below is short list of common payloads and linkers available for immediate purchase (GMP or non-GMP). For the full list of “ready-to-conjugate” chemical entities please fill out the “Request a Quote” form.

Key Payloads

MMAE, MMAF, Exatecan, DM1, DM4, SN38, PNU, PBD, Eribulin, PBD Dimers (2033*) and Calicheamicin

Key Linkers

Val-Cit based, Val-Ala-Based-PnP/PFP, PEG based, GGFG based
SMCC, Hydrazone based, Glutathione, Long chain Amino acid, Sugar based

Key Payloads and Linkers

MC-VC-PAB-MMAE, M-PEG-VCP-Eribulin, MC-GGFG-Exatecan, MC-MMAF, SMCC-DM1, MC-PEG-VC-Exatecan, Tesirine (2033) *, CL2A-SN38, GGFG-DXd (2033)*, SPDB-DM4

Registered DMF

42606

MMAE

42769

MMAE

42618

Payload-linker vcMMAE

42678

Payload-linker vcMMAE

40532

MC-GGFG-Exatecan

43548

MC_GGFG_Dxd

44127

Mertansine (DM1)

44126

DM1-SMCC

Non-GMP and
GMP Manufacturing
Available

For the full list of “ready-to-conjugate” chemical entities please fill out the “Request a Quote” form.

*Patent expiration year

Customized Payload & Linker Services

As a one-stop CRDMO (Contract Research, Development and Manufacturing Organization), we also offer customized payload, linker and payload-linker discovery, development and manufacturing services utilizing hundreds of dedicated and highly trained scientists and engineers.

Our specialized small molecule R&D and manufacturing teams have deep experience in the identification, optimization and commercialization of NCEs (new chemical entities) or existing chemical payloads and linkers and have extensive know-how for the design of proprietary synthetic routes. Our enabling technologies and capabilities include:

Flow chemistry (hydrogenation, condensation, deprotection, etc.)
Bio/Chem-catalytical process screening and application
Solid-state chemistry study, crystalline process development

With OEB 5 protection within our laboratories and GMP manufacturing suites, efficient project management systems, expertise for right-first-time execution and uncompromised quality, WuXi XDC has an extensive history of providing on-time delivery of customized molecules for your various R&D and GMP manufacturing needs.

Scaffold Library for Branched Linkers For Dual-Payload ADCs

Dual-payload ADCs stand out in cancer therapy for their potential to target multiple pathways or overcome resistance—yet their development demands precise payload conjugation and controlled DAR, key challenges in manufacturing.

WuXi XDC’s Scaffold Library for Branched Linkers addresses these hurdles head-on. Our linkers enable sequential/simultaneous payload conjugation, leveraging selective deprotection (for controlled DAR) and orthogonal click chemistry for reliable production.

Diverse, updated linkers fit preclinical-clinical needs. Backed by experts, we deliver end-to-end support—speeding R&D, cutting costs, and advancing dual-payload ADC therapies.

Accelerate dual-payload ADC design via diverse, standardized scaffolds for faster screening
Enable precise payload ratio control and optimized synergistic effects
Reduces R&D costs/risks through simplified synthesis and optimized SAR

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