X-LinC

Bioconjugation Discovery
Bioconjugation Process Development
Analytical Development
Formulation and DP Development
GMP mAb Intermediate and Conjugation Manufacturing
GMP Formulation, Fill and Lyophilization
Payload and Linker R&D and Manufacturing
Ready-Made Payloads & Linkers

X-LinC

Novel Thiol Reactive Connector

The commonly employed maleimide-thiol conjugation in ADCs is susceptible to retro-Michael addition—a reversible reaction that leads to compromised efficacy and off-target toxicity. WuXi XDC addresses this inherent instability through our proprietary X-LinC connector technology. This innovative solution has demonstrated superior plasma stability, high conjugation efficiency, and seamless compatibility with WuXiDARx.

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