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Poster modified on 07/05/2026
Seamless Integration of Antibody Purification and Antibody-Drug Conjugation
| Traditional ADC manufacturing involves a highly complex, multi-stage workflow: antibody intermediate production, payload-linker synthesis, ADC drug substance manufacturing, and final drug product manufacturing. Manufacturing each of the 4 components—monoclonal antibodies(mAbs), payload-linkers, drug substance, drug product— demands different expertise, dedicated facilities, quality control and release. In some cases, mAb purification and conjugation processes apply redundant column purifications, resulting in a long and complicated process. This redundancy leads to inefficient operations and high manufacturing costs. At WuXi XDC, our team has innovated and streamlined an integrated manufacturing process, which smartly combined mAb purification process and antibody-drug conjugation process, effectively reducing some redundant column and UF/DF steps. This significantly shortens development timeline, reduces the time needed for manufacturing ADC, and lowers the manufacturing cost. |
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