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Ready-Made Payloads & Linkers
Order now our high-quality GMP and non-GMP grade “Ready-to-Conjugate” Chemical Payloads, Linkers and Payload-Linkers
WuXi XDC offers a growing library of common payloads and linkers for use in a variety of R&D and pharmaceutical purposes including use as chemical intermediates in the production of antibody drug conjugates (ADCs) and other bioconjugates. These ready-to-use small molecule entities are available in inventory as either GMP- and non-GMP grade.
Payloads and Linkers
Below is short list of common payloads and linkers available for immediate purchase (GMP or non-GMP). For the full list of “ready-to-conjugate” chemical entities please fill out the “Request a Quote” form.
Payloads
MMAE*, VC-MMAE*, MMAF, MC-MMAF*, DM1, DM4, SN38, Exatecan mesylate (DX-895 1f)*, PNU159682, PBD, and Teserine.
Linkers
MC-VC-PAB-PNP, Glu-VC-PAB, NHS-Glu-VC- PAB, Azido-Glu-VC-PAB, Hydrazone (acid sensitive), Disulfide (glutathione sensitive), SMCC and Fmoc-VAL- ALA-PAB-PNP
*Drug Master File (DMF) is available with specific regulatory agencies. Please contact us (see submission form on the right) for more information.
Customized Payload & Linker Services
As a one-stop CRDMO (Contract Research, Development and Manufacturing Organization), we also offer customized payload, linker and payload-linker discovery, development and manufacturing services utilizing hundreds of dedicated and highly trained scientists and engineers.
Our specialized small molecule R&D and manufacturing teams have deep experience in the identification, optimization and commercialization of NCEs (new chemical entities) or existing chemical payloads and linkers and have extensive know-how for the design of proprietary synthetic routes. Our enabling technologies and capabilities include:
- Hydrogenation
- Flow chemistry
- Bio-catalysis
- Chemo-catalysis
With OEB 5 protection within our laboratories and GMP manufacturing suites, efficient project management systems, expertise for right-first-time execution and uncompromised quality, WuXi XDC has an extensive history of providing on-time delivery of customized molecules for your various R&D and GMP manufacturing needs.
Scaffold Library for Branched Linkers For Dual-Payload ADCs
Dual-payload ADCs stand out in cancer therapy for their potential to target multiple pathways or overcome resistance—yet their development demands precise payload conjugation and controlled DAR, key challenges in manufacturing.
WuXi XDC’s Scaffold Library for Branched Linkers addresses these hurdles head-on. Our linkers enable sequential/simultaneous payload conjugation, leveraging selective deprotection (for controlled DAR) and orthogonal click chemistry for reliable production.
Diverse, updated linkers fit preclinical-clinical needs. Backed by experts, we deliver end-to-end support—speeding R&D, cutting costs, and advancing dual-payload ADC therapies.
- Accelerate dual-payload ADC design via diverse, standardized scaffolds for faster screening
- Enable precise payload ratio control and optimized synergistic effects
- Reduces R&D costs/risks through simplified synthesis and optimized SAR
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