Discovery efforts of antibody-drug conjugates (ADCs) and other bioconjugates require broad expertise across multiple disciplines including antibody discovery, payload-linker design and synthesis, the subsequent conjugation, followed by in vitro and in vivo characterization studies. Scientists constantly experience a lot of challenges during years of discovery process, such as fragmented CRO network, challenging conjugation, and analytical characterization for diversified moieties etc. WuXi XDC has built an integrated bioconjugate discovery platform that includes all these in one team.
Beyond the single payload conjugation, WuXi XDC also accumulated rich experiences on generating hundreds of bispecific ADCs with 20+ different BsAb formats, dual-payload ADCs and thousands of novel bioconjugate modality molecules, including AOC, DAC, APC, with diversified conjugation approaches.
WuXi XDC’s integrated bioconjugate discovery platform, conjugation expertise and developability assessment toolbox enables seamless alignment and accelerates the ADC and bioconjugate drug discovery process.