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Bioconjugation Discovery Services

Bioconjugate Discovery Services


Integrated ADC/Bioconjugate Discovery Services

 
As a trusted antibody drug conjugate CRO and CDMO, our ADC discovery services integrate all discovery functions within a unified single platform to deliver seamless workflows, expedited decision-making, fewer development bottlenecks, and lower costs and shorter timelines from initial concept through to candidate selection. Complemented by our end-to-end ADC conjugation services, we are able to compress the timeline from target identification to fully characterized ADC candidates down to 8–10 months, empowering our partners to realize faster, more efficient therapeutic innovation.

 


ADC lead selection timeline: ~10 months for one round

1

Antibody Production

  • mAb, BsAbs, recombinant proteins, Antibody fragments
2

Payload-linker Synthesis

  • Extensive payload-linker library
  • Customized payload linkers
3

Bioconjugation

  • Multiple conjugation methods
  • Proprietary technology to improve homogeneity
  • High-throughput conjugation technology
4

In vitro Biological Characterization

  • ELISA, flow cytometry, surface plasmon resonance
  • Internalization
  • In vitro killing
5

In vivo Pharmacological Characterization

  • Efficacy models
  • PK/PD
  • Toxicity
6

Physiochemical & Developability Characterization

  • Understand physiochemical properties
7

Preclinical Candidate


    Extensive Conjugation Capabilities

    The discovery services team at WuXi XDC applies multiple synthesis methods to generate bioconjugates linking payloads to biologics, which include proteins (e.g., antibodies, fusion proteins), peptides, polynucleotides, among others. We use many types of conjugation technologies including traditional cysteine conjugation and lysine conjugation, and many of the widely used site-specific conjugation methods. We support development across various carrier formats, complemented by an extensive library of linkers and payloads available to advance your R&D programs, as summarized in the table below.


    Comprehensive Capabilities and Vast Project Experiences from ADC to XDC
     
    From ADC to XDC, the boundaries of bioconjugates are continually expanding. At WuXi XDC, we have conducted a vast array of projects across bioconjugation landscape. Our capability from ADCs to XDCs:

     

    • ADC/BsADC
    • Antibody-Oligonucleotide Conjugate
    • Antibody-Chelator Conjugate
    • Degrader Antibody Conjugate
    • Immuno-Stimulant Antibody Conjugate
    • Antibody-Peptide Conjugate
    • Vaccine Conjugate
    • PEGylation-Based Conjugate
    • Protein-Protein Conjugate
    • Antibody-Glycan Conjugate
    • Antibody-Fluorophore Conjugate
    • Peptide-Oligo Conjugate
    • and more…

     

    Related Resource
     

     

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