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XDC Academy

Dual-Payload ADCs and WuXi XDC’s capability in dpADCs
Dual-Payload ADCs and WuXi XDC’s capability in dpADCs
Oct. 21, 2025

A Dual-Payload Antibody-Drug Conjugate (dpADC) is an advanced cancer therapy engineered to deliver two distinct cytotoxic agents simultaneously to a cancer cell using a single antibody. This innovative approach is designed to overcome critical limitations of conventional treatments, such as drug resistance and tumor heterogeneity.

 

The field of dpADCs is rapidly expanding. As of August 2024, the pipeline has grown significantly, with two candidates advancing to the clinical stage and 78 in preclinical development.
 
This deck provides a comprehensive overview of dpADCs, detailing their mechanism of action, key advantages, and the competitive landscape. It also highlights WuXi XDC’s cutting-edge capabilities in dpADC development and our broader expertise in bioconjugate platforms. Discover how WuXi XDC is pioneering progress in this transformative therapeutic modality.

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