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Scientific Poster Download
Poster modified on 15/04/2026
Compatibility Study for Routine Analytical Testing of Payload-Linker Products
Due to their unique structural design, ADC payload‑linkers are highly susceptible to multiple degradation pathways, including hydrolysis, oxidation, moisture uptake, and photodegradation. These risks must be addressed during chromatographic method development to ensure stability‑indicating, reliable analysis.
Here, we highlight representative analytical challenges observed in routine testing, propose potential degradation mechanisms, and demonstrate strategic solutions to guide robust method development.
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