Next-generation targeted conjugates, including dual-payload ADCs, antibody–oligonucleotide conjugates(AOCs), and antibody–peptide conjugates (APCs), are emerging as promising approaches to address unmetmedical needs. Their discovery remains challenging due to their molecular complexity and the need for crossfunctionalexpertise.
In this scientific poster, we present WuXi XDC’s integrated discovery platform spanning payload–linker design, conjugation, purification, analytical characterization, and in vitro and in vivo biological evaluation, enabled by multidisciplinary expertise, extensive bioconjugation experience, and proprietary conjugation and linker technologies.
By integrating these capabilities within a single platform, we accelerate the discovery and optimization of next-generation targeted conjugates from concept to preclinical candidate in 10 months. We have advanced over 100 programs from Discovery to CMC.